• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention is a cosmetic emulsion product, the aqueous phase of which contains 0.05 -1 5% by weight of bär berry extract and 0.5 -12.5% by weight of alum. The product prepared according to the invention is applicable for the cosmetic treatment of deformities caused by varicose veins.
    公开号:SE1100266A1
    申请号:SE1100266
    申请日:2011-04-08
    公开日:2011-10-09
    发明作者:Peter Varnai；Ernoe Orban
    申请人:Promedic Naturlaekemedel I Huskvarna Ab；
    IPC主号:
    专利说明:

    1015202530However, only a few methods can be applied as a local treatment for the disease.
    The local application of alum, also known as potassium aluminum sulfate[AlK (SO4) 2-12 H 2 O] is one of them. Alum is a well-known and widely used compoundin both the pharmaceutical and cosmetic industries, and is recognized by all pharmacopoeiasand cosmetic standards worldwide. It is used as an ingredient in variouscreams, powders and solutions. Due to its anti-inflammatory and anti-edema effectsDermatology and cosmetics are its main areas of application. Due to its astringentit is also widely used as a hemostatic agent; it isalso useful for cleansing skin and mucous membranes if dissolved in water.
    Products containing alum have been described in U.S. patents (eg 462643 3); andHungarian patents 208489, 208251 and 206980 describe the preparation method forproducts containing alum for the treatment of varicose veins. A common disadvantage of thesemethods, however, are that alum does not completely dissolve in these products and small alumbarley can damage the skin; in addition, the biological utilization of these grains is negligible.
    A solution to this problem has been described in Hungarian patents 208490 and 214342.
    The former patent describes a method in which a particular surfactant, together with aappropriate amount of alum provides a way to prepare an oil in water emulsion, whichlacks alum grains. Patent 214342 does not use alum, but aluminum chloride, and theyprepares an aluminum complex.
    Regarding the effectiveness of the chemical compounds, various plant extracts have been used inthese products to enhance the effects of alum. Hungarian patent 206,980 describes amethod, in which distributed alum, as well as leaf extracts from different plants (hazel, rye,pagoda trees, blueberries) are used to prepare an ointment. Using this method canointments are prepared which are effectively applicable to the treatment of inflammatorystanding in the lower extremities. The effectiveness of the ointments is comparable to that ofAurobin (contents: prednisolone kapronikurn, lidocalin chloratum, dexpantenol, triclosan)and the main advantage of the product is the lack of side effects that are causedof certain ingredients in Aurobin.1015202530Hungarian patent 208,489 also describes the method of preparation of an ointment containingholds various plant extracts (yarrow and / or marigold oil a). The ointment contains 0.0l-0.5%herbal extracts and 1-15% aluminum salt (alum, aluminum sodium acetate tartarate and aluminumnium acetate). It may be obvious from the previously mentioned examples that the authorsdid not take into account the solubility limits of alum in water, therefore the product contains asprepared in accordance with the patent - in addition to alum dissolved in water and dispersed inthe base - even solid alum grains, which can damage the thin skin over the diseased area atlubrication, and this can lead to injuries and bleeding on the leg.
    Hungarian patent 214342 aims to eliminate the disadvantages arising from suspensionproperties of the ointment prepared according to patent 208489. For this purpose proposesthe preparation of a water-soluble aluminum complex, which is less irritating than thatoriginal aluminum chloride. A disadvantage of the method, compared to alum contentproducts, is that the pH of products prepared in accordance with the description isextremely low (pH 2.8-3.5), and repeated application of the product can lead to irritationtion. The description also states that by adding extract of amicarot and lavenderoil, the efficiency of the product can be further enhanced.
    According to Swedish patent 526 349, alum has combined with extract of red vine leaves (Extraitde Vigne Rouge) an enhanced effectiveness against varicose veins deformities,compared with the variation with the same concentration but only containing alum. Thehowever, no specific evidence has been provided. The method also has a major problem withits feasibility, some of the implementation examples contradict practical andscientifically accepted experience. According to the scientific literature (Martindale,The Complete Drug Reference, 35th ed., P. 1941) is sodium lauryl sulfate, one ofthe main ingredients of the anionic emulsion ointment, incompatible with aluminumnium ions; therefore, the surfactant effect of the surfactant decreases elongated andleads to the separation of the cream into two phases. The product prepared in accordance withwriting is useful only for a very limited time.10152025304In summary, in the case of the aforementioned patents,the extracts contribute to the effectiveness of these products, based on their characteristics,and no extraordinary or surprising effects have been reported.
    The patents described above do not specify how often the products should be applied. The commonthe same disadvantage of the commercially available products, prepared in accordancewith the patents, is that they must be applied fl your times a day. According to the patientStepton (OGYI-275/1992), prepared on the basis of patent 208490, bothas Stepton Plus (OGYI-967/2006), which are ointments for varicose veins, applied 3-5 timesa day. Based on the application information for the KALMIL ointment for varicose veins(OÉTI: 4079/2006), prepared in accordance with patent 214342, this shall be appliedfl your times (at least 2-3 times) a day (it should be noted that another disadvantagewith the product is irritation upon repeated application). It is obvious that applicationmore than 2 times a day is usually difficult to incorporate into the daily routines of most peoplepeople. In addition, since these products are for the cosmetic treatment ofjudgment oxygen, the repeated application of these ointments is also important.
    There is therefore a need for more efficient, new products. Efficiency means in thiscases longer effect, so that application only twice a day should be sufficient forthe desired effects.
    During our experiments, we prepared emulsions containing alum and plant extracts.
    The following plant extracts (from fruits) were used:1st female (Angelica archangelica L.)2. fl feather (Sambucus nigra L.)3. ek (Quercus robur L.)4. libsticka (Levisticum of K cinale Koch)5. mariatistel (Silybum marianum L.)6. hagtom (Crataegus monogina J acq.)1015202530Examination of these substances revealed the sample containingaluii / fl currant extract have the most effective astringent effect.
    Our results are completely unexpected and surprising, because fl currants and extracts do not haveindicated as substances useful for the treatment of hernias. There is onedocument (International Publication No. nurrirner WO01 / 52872), in which acontaining cream has been suggested for the treatment of hemorrhoids; the cream containshowever, 3 additional plant extracts and the description does not provide an overview of themassumed effects for only the der currant extract.
    The conclusion to use fl currant extract for cosmetic treatment of varicose veins is derivedfrom the significant number of active biological components therein.
    Quality requirements for fl feather (Sambucus nigra L.) Extractum Sambuci Fructusdescribed in the Hungarian and European food books. The extract is a dark purple,water-soluble, fi nt powder, prepared by vacuum drying of der currant uice. Itsbiologically active substances are donors, polyphenols, on avonoids, anthocyanides, antioxidantsdanter, vitamins and carotenoids (Fitoterápia 3, 72-79; J. Ethnopharmacology 73,479-485; Olaj, Szappan, Kozmetika 53, 33-36).
    According to the above-mentioned facts, the invention is a product containing alum and derberry extract. Taking into account the description of the existing technology, the product is aemulsion and does not contain alum. Therefore, the invention is an emulsion for cosmetictreatment, the aqueous phase of which contains 0.05-15% by weight of fl currant extract and 0.5-12.5weight% alum. The product also contains excipients, emulsifiers and in some casesother substances that are common components in cosmetic products.
    From a practical point of view, it is important that the products are stable for a relatively long time.
    Certain modifications to the composition of a product described in patent 208490can meet the above requirements. According to the patent, the type of emulsifier is asis added important for the stability of the product. Therefore, cetyltrimethylammonium chloride was added1015202530and / or cetyltrimethylammonium bromide as emulsifier in the aqueous phase of the product.
    Such a composition is described in Example 1.
    Another promising solution is based on the addition of non-ionic emulsifiers; onestable emulsion can be prepared in such a way that a complex film layer is formed on the surface ofthe dispersed particles of the surfactants.
    This can be accomplished by using hydrophobic (oil-soluble) emulsifiers.oil phase ("A") agents and hydro (water soluble) water phase emulsifiers(IIBH).
    It is advantageous when the aqueous phase in the emulsion contains 0.5-10% by weight of water-soluble,non-ionic emulsifiers and the oil phase contain lipid-like excipients and0.5 -20% by weight of oil insoluble, non-ionic emulsifiers. The active componentsis present in the aqueous phase of the emulsion. The emulsion may also contain other common excipients.ser, e.g. preservatives.
    The emulsion is prepared in such a way that the lipid-like components described in"A" (eg white petrolatum, isopropyl myristate, cetylstearyl alcohol, cetyl alcohol, isopropyl alcoholpalmitate, etc.) and hydrophobic emulsifiers (eg diethylene glycol monopalmitate,glycerol monostearate, lanolin alcohol, lecithin, ethyl linolate, glycerol oleate) is heated to80 ° C in a learning vessel and homogenized after being fi completely melted.
    The aqueous phase "B" should be prepared in a similar manner. In this case, the entire amount of waterheated to 70 ° C. The hydraulic emulsifiers (eg polyoxyl 15-hydrostearate,macrogol monomethyl ether, polyoxy-40-hydrogenated castor oil a, polyoxyl-35-castor oil a,polyoxyl-20-cetylstearyl ether, etc.), alum, der currant extract and the corresponding substanceto protect the product against bacteria (eg methyl or ethyl parahydroxybenzoate, cetyl-trimethylaminium bromide [cetrimonium bromide] or cetyltrimethylammonium chloride[cetrimonium chlorideD should be dissolved in this hot water.1015202530The phases prepared as described should be mixed with vigorous stirring on onesuch that the smaller volume phase is added to the larger volume phase.
    The mixture prepared in this way must cool slowly - continuouslystirring - to about 30 ° C. The emulsion should be poured into metal-free, lockable containers, andshould be stored between 15 ° C - 25 ° C, protected from light and air.
    The following are some (but not limited) examples of the ingredients in the productaccording to the invention.
    Example 1Emulsion components"A"cetylstearyl alcoholisopropyl myristatewhite Vaseline"B"alumfl currant extractcetyltrimethylamminium bromideclean waterExample 2Emulsion components"A"diethylene glycol monopalmitateglycerol monostearateisopropyl myristatecetylstearyl alcoholwhite Vaselineweight-%11.08.020.05.02.03.051.0weight-%1.01.02.51.54.01015202530"B"polyoxyl hydroxy stearatealumfl currant extractmethyl parahydroxybenzoateethyl parahydroxybenzoateclean waterExample 3Emulsion components1. A "diethylene glycol monostearatelanolin alcoholcetyl alcoholalmond oillevomenolwhite Vaseline"B"macrogol monomethyl etheralumfl currant extractmethyl parahydroxybenzoateethyl parahydroxybenzoateclean water1.09.015.00.20.164.7weight-%1.02.05.55.00.512.01.57.012.00.20.153.21015202530Example 4Emulsion components"A"lecithin (E 322, E 442)stearyl alcoholglycerol monooleateisopropyl palmitatewhite VaselineHB "Weight-%4.07.52.57.021.0polyxyl-40-hydrogenated castor oil 2.0alumfl currant extractmethyl parahydroxybenzoateclean waterExample 5Emulsion componentsHAVE..ethyl linolateglycerololeatecetyl alcoholisopropyl palmitatewhite VaselineHB ..macrogol-1S-hydroxystearatealumfl currant extractmethyl parahydroxybenzoatefeflt Water6.14.00.245.7weight-%6.012.013.014.228.83.02.50.10.320.1101520253010Example 6Emulsion components"A"% by weightlanolin alcohol l 8.6glycerololeate 16.5cetylstearyl alcohol 9.4ethyl hexyl stearate 6.0white Vaseline 39.5HB ..polyoxyl-ZO-cetylstearyl ether 1.00alum 0.50fl currant extract 0.10cetrimonium bromide 0.05pure water 8.35Emulsions prepared according to Examples 1-6 underwent stability tests:the products were stored at 25 ° C (0.1 ° C) at isotene temperature, protected from light andair in polypropylene containers for 37 months.
    Microscopic examination of samples taken at 30-day intervals revealed thatphase division (fl occlusion) did not take place at any time during the storage period. Producttheir stability therefore meets the requirements for their future use. Emulsionemamissing came that would damage the skin.
    The cosmetic applicability of the emulsions prepared according to Examples 1-5, onThe symptoms of varicose veins were examined in a 1-month study, which included 36patients who showed mild symptoms of varicose veins. The study included 23 womenand 13 male patients aged between 23 and 69 years.101520253011The alum-containing ointment registered by the National Institute of Phannacy(OGYI-275/1992) was chosen as an ironmongery product to test the effectiveness of thethe various emulsions prepared according to the examples.
    Test products were applied to the extremity in such a way that a thin layer of the ointmentwas gently massaged into a thoroughly cleaned area for one minute, followed by 10 minutes of rest.
    The procedure was repeated twice a day, in the morning and early afternoon.
    The results obtained from our emulsions and the reference ointment were compared.
    The fragility of small blood vessels (arterioles, venules and capillaries) was also examineduse of a petechiometer for 15 patients (10 women and 5 men). The measurementswas performed at the beginning of the test and 7 days after the first treatment.
    The results clearly show that both the emulsions described above and thethe cream was proven to have an astringent effect on the venules. Significant differences are observedhowever, both in terms of efficiency and duration of effect.
    The emulsion prepared by us was shown to be obviously more effective in reducing itthe swelling caused by the veins and its beneficial effects also lasted longer.
    The comparison product was only able to produce a visible, astringent effectfor 2-3 hours, while the products prepared according to Examples 1 and 5 have the sameeffect for 6-7 hours. Therefore, the duration of the effect was shown to be 2-3 times longer.
    We can conclude that by regular application of the emulsion according totreatments, only twice a day (in the morning and in the afternoon)day) be sufficient, while similar products must be applied 3-5 times overdays (Gyógytermék Vademecum Ed .: Országos Gyógyszerészeti Intézet 1995, 209 och262). This characteristic is beneficial for the patients, has a positive effect on theireveryday life and makes the treatment schedule considerably simpler.12The beneficial cosmetic effects of the emulsion in question have also been confirmedby examination with instruments: after a 2-day application of the emulsionno petechiae were observed at 30 mm Hg negative pressure.
    In summary, the product significantly reduces swelling of the veins and discomfort such asassociated with varicose veins, and although its effects are transient, one can be significantcosmetic correction is achieved with regular application.
    权利要求:
    Claims (4)
    [1]
    An emulsion product for cosmetic purposes, the aqueous phase of which contains 0,05-15% by weight of fl currant extract and 0,5-12,5% by weight of alum.
    [2]
    Emulsion product according to claim 1, containing 0.1-2% by weight of fl currant extract.
    [3]
    Emulsion product according to Claim 1 or 2, containing cetyltrimethylammonium chloride and / or aqueous phase cetyltrimethylammonium bromide as emulsifier.
    [4]
    Emulsion product according to claim 1 or 2, containing 0.5-10% by weight of water-soluble, non-ionic emulsifier in the aqueous phase and lipid-like excipients and 0.5-20% by weight of oil-soluble, non-ionic emulsifiers in the oil phase.
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    同族专利:
    公开号 | 公开日
    HU1000189D0|2010-05-28|
    HU1000189A2|2011-10-28|
    SE535256C2|2012-06-05|
    HU228081B1|2012-10-29|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    CN103610049A|2013-11-26|2014-03-05|刘克武|Elderberry fruit oil oral emulsion and preparation method thereof|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    HU1000189A|HU228081B1|2010-04-08|2010-04-08|Emulsion composition comprising elder-berry extract and alum and using for cosmetic treatment vein|
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